The Science Behind Rejuran

Our Professional Line of anti-aging products is unsurpassed due to our proprietary DNA Fragments Optimizing Technology (DOT™), used to create our patented, regenerative Hydrolyzed DNA.

The process begins by obtaining the highest purity Hydrolyzed DNA from wild Chum Salmon (Oncorhynchus keta) using Rejuran DOT™. We choose Chum Salmon as its DNA closely matches human nucleotides of Adenine, Cytosine, Guanine, and Thymidine (ACGT), making it the best choice for regenerative skin health.

Effects of Hydrolyzed DNA

  • Proven to be the most compatible with human skin (95% similarity) without adverse effects.
  • Stimulates skin’s own reparative and restorative capabilities
  • Improves skin turnover cycle.
  • Skin elasticity improved by recovering the optimal biological condition of the dermis and epidermis.
  • Reduces inflammation to alleviate skin irritation
  • Reinforces skin's own barrier function
  • Reduces the appearance of fine lines and wrinkles
  • Helps increase and retain moisture for glowing skin

How does Hydrolyzed DNA Work?

Hydrolyzed DNA helps by rapid and complete recovery of normal tissues.

Hydrolyzed DNA Clinical Studies

Korean Study
Scar Treatment
Elasticity Restoration
Melanin Improvement
Skin Normalization
Dead Cell Improvement
Moisture Improvement
Sagging Improvement
Skin Revitalization
The Korean Dermatology Research Institute was commissioned to research and report the clinical tests of REJURAN® Healer Turnover Ampoule by Pharma Research Products, noting items such as: improvement of damaged skin, turnover cycle of improving stratum corneum, density of the dermal layer, moisture level of 0.5mm inner layer of the skin, elasticity level of 1 mm inner layer of the skin and dermis, improvement of wrinkles; eye wrinkles, nasolabial folds, skin freckles and pigmentation, facial lifting effect, skin softness and skin brightness.

Scar Improvement

Vancouver Scar Scale

Scar Height Improvement

3d Image Analysis

Ref ) Preventive Effect of Polynucleotide on Post-thyroidectomy Scars: A Randomized, Double-Blinded, Controlled Trial Lasers inSurgery and Medicine (SCI), 2018, 755-762

The experimental group and control group were randomly assigned to compare the efficacy for 16 weeks:

Experimental group: fractional laser + REJURAN

Control group: fractional laser + saline
The Vancouver Scar Scale (VSS), global photographic assessment, and objective scar were assessed using 3D camera at baseline and after surgery
Adjuvant administration of PN along with conventional fractional laser treatment led to more favorable effect in would healing and post-operative scar prevention after thyroidectomy

Skin Elasticity Restoration

DOT™ Hydrolyzed DNA in REJURAN® products restores the appearance of thinned, damaged skin and improves elasticity, resulting in a visibly regenerated epidermis and dermis.

Melanin Improvement

Skin Normalization

DOT™ Hydrolyzed DNA in REJURAN® Healing Essence increases the appearance of epidermal and dermal skin thickness. This supports a stronger defense barrier against environmental and non-environmental factors that cause premature skin aging.

Dermal Thickness

Epidermal Thickness

Skin Dead Cells Improvement (%, mean)

Moisture Improvement

Sagging Improvement (%, Mean)

Skin Revitalization

DOT™ Hydrolyzed DNA in REJURAN® Healing Essence promotes optimal cell growth through fibroblast proliferation which invigorates collagen production.

Fibroblast Proliferation

Healing Essence

Hydrolyzed DNA

  • ✔Excellent Recovering Effect
  • ✔Improvement of Skin Elasticity and Appearance of Fine Wrinkles
  • ✔Natural Skin Beauty Effects
  • ✔Improvement of Skin Tone and Texture

Skin Booster

Hydrolyzed DNA

  • ✔Supports natural cellular regeneration
  • ✔Provides nutrients essential for collagen production & retains moisture
  • ✔Gives skin a more elastic look
  • ✔Reduces the appearance of wrinkles

Trueskin Essence

Hydrolyzed DNA

  • ✔Reduces the appearance of wrinkles and fine lines
  • ✔Supports a balanced cellular turnover cycle
  • ✔Promotes optimal hydration balance
  • ✔Natural lifting and volumizing effect

Tone-Up Booster

Hydrolyzed DNA

  • ✔Evens and brightens skin tone
  • ✔Helps strengthen skin’s natural barrier
  • ✔Reduction of hyperpigmentation spots
  • ✔Hydrates and soothes skin for a soft, supple feel

Healing Care Set

Hydrolyzed DNA

  • ✔Helps reduce dark spots and even skin tone
  • ✔Strengthens skin’s natural barrier for enhanced resilience
  • ✔Visibly reduces wrinkles, sagging, and other signs of aging
  • ✔Deeply hydrates and nourishes for a smoother, youthful glow